abstract：PURPOSE:this study aimed to investigate the effect of antivirals ritonavir and lopinavir/ritonavir on the pharmacokinetics and pharmacodynamics of oral oxycodone, a widely used opioid receptor agonist used in the treatment of moderate to severe pain. METHODS:a randomized crossover study design with three phases at int...

journal_title：European journal of clinical pharmacology

authors： Nieminen TH,Hagelberg NM,Saari TI,Neuvonen M,Neuvonen PJ,Laine K,Olkkola KT

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to analyse inter-and intra-country quantitative and qualitative differences in anti-asthmatic prescriptions to children and adolescents. METHODS:A literature search was performed in EMBASE and MEDLINE to identify pharmaco-epidemiological studies published from January 1, 2000 ...

journal_title：European journal of clinical pharmacology

authors： Bianchi M,Clavenna A,Bonati M

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the elderly. NSAIDs may cause a series of adverse drug reactions, of which gastrointestinal, renovascular/cardiovascular and bleeding complications are of particular concern. Concomitant use of several other drugs may further increase the risk...

journal_title：European journal of clinical pharmacology

authors： Vandraas KF,Spigset O,Mahic M,Slørdal L

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Reimbursement databases are potentially invaluable tools to develop and conduct pharmacoepidemiological studies on drug use. However, two types of factors that may influence the performance of a database can be distinguished: firstly, factors related to the constitution of the database, and secondly, facto...

journal_title：European journal of clinical pharmacology

authors： Latry P,Molimard M,Bégaud B,Martin-Latry K

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To illustrate the interface of pharmacogenetics and therapeutic drug monitoring and to estimate target blood level for imatinib in the treatment of chronic myelogenous leukemia METHODS:A literature review to provide the evidence and necessary data to support the case for the interface, and quantitative analysi...

journal_title：European journal of clinical pharmacology

authors： Li-Wan-Po A,Farndon P,Craddock C,Griffiths M

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:To evaluate zolpidem as a mechanism-based inactivator of human CYP3A in vitro, and to assess its metabolic interaction potential with CYP3A drugs (in vitro-in vivo extrapolation; IV-IVE). METHODS:A co- vs. pre-incubation strategy was used to quantify time-dependent inhibition of human liver microsomal (HLM)...

journal_title：European journal of clinical pharmacology

authors： Polasek TM,Sadagopal JS,Elliot DJ,Miners JO

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:We investigated the role of genetic, physiological, environmental, and epigenetic factors in regulating CYP2A6 expression and nicotine metabolism. METHODS:Human livers (n = 67) were genotyped for CYP2A6 alleles and assessed for nicotine metabolism and CYP2A6 expression (mRNA and protein). In addition, a subset...

journal_title：European journal of clinical pharmacology

authors： Al Koudsi N,Hoffmann EB,Assadzadeh A,Tyndale RF

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. We review the characteristics of the gene coding for HTR1B, its product and the functional role of HTR1B in the neural networks involved in motivation and memory; the cent...

journal_title：European journal of clinical pharmacology

authors： Drago A,Alboni S,Brunello N,De Ronchi D,Serretti A

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To investigate whether the CYP3A4*1G genetic polymorphism contributes to the variability in CYP3A activity and response to fentanyl. METHODS:One hundred and forty-three gynecologic patients who were scheduled to undergo abdominal total hysterectomy or myomectomy with general anesthesia were enrolled in this st...

journal_title：European journal of clinical pharmacology

authors： Zhang W,Chang YZ,Kan QC,Zhang LR,Li ZS,Lu H,Wang ZY,Chu QJ,Zhang J

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Until recently, ondansetron was approved for the prevention of nausea and vomiting only in patients older than 2 years. However, as the use of ondansetron in patients younger than 2 years had been documented, characterization of ondansetron pharmacokinetics in this younger pediatric age group was warranted. ME...

journal_title：European journal of clinical pharmacology

authors： Mondick JT,Johnson BM,Haberer LJ,Sale ME,Adamson PC,Coté CJ,Croop JM,Russo MW,Barrett JS,Hoke JF

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the influence of clinical and genetic factors on warfarin dose requirements in the Japanese population. METHODS:We enrolled 125 patients on stable warfarin anticoagulant therapy with an international normalized ratio maintained between 1.5 and 3.0. PCR-based methods w...

journal_title：European journal of clinical pharmacology

authors： Ohno M,Yamamoto A,Ono A,Miura G,Funamoto M,Takemoto Y,Otsu K,Kouno Y,Tanabe T,Masunaga Y,Nonen S,Fujio Y,Azuma J

更新日期：2009-11-01 00:00:00

abstract：AIM:To analyse the consumption of a number of medicines with a known potential for increasing the risk of road traffic accidents in the general population of Europe. METHODS:Questionnaires were distributed through the European Drug Utilization Research Group (EuroDURG) and Post-Innovation Learning through Life-events ...

journal_title：European journal of clinical pharmacology

authors： Ravera S,Hummel SA,Stolk P,Heerdink RE,de Jong-van den Berg LT,de Gier JJ

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:The aims of the present analysis were to determine prevalence of transaminase elevation in placebo-treated healthy volunteers in our historical phase I clinical trials and to assess which factors were associated with it. METHODS:We performed a retrospective analysis of alanine transaminase (ALT) levels in 481 ...

journal_title：European journal of clinical pharmacology

authors： Cai Z,Christianson AM,Ståhle L,Keisu M

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:We have developed a model for integrated medicines management, including tools and activities for medication reconciliation and medication review. In this study, we focus on improving the quality of the discharge summary including the medication report to reduce medication errors in the transition from hospital...

journal_title：European journal of clinical pharmacology

authors： Bergkvist A,Midlöv P,Höglund P,Larsson L,Bondesson A,Eriksson T

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:To correct overdosing of drugs requiring adjustment based on renal function in intensive-care patients. METHODS:In a prospective intervention study, we estimated individual glomerular filtration rate and assessed whether medication required dose adjustment based on renal function. Senior clinicians received a ...

journal_title：European journal of clinical pharmacology

authors： Bertsche T,Fleischer M,Pfaff J,Encke J,Czock D,Haefeli WE

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:To compare plasma levodopa concentrations after repeated doses of levodopa/carbidopa/entacapone (LCE) and levodopa/carbidopa (LC). METHODS:Open-label, randomized, two-period, active-controlled, cross-over study with four dosing regimens: groups I and II (healthy volunteers and Parkinson's disease patients) ...

journal_title：European journal of clinical pharmacology

authors： Kuoppamäki M,Korpela K,Marttila R,Kaasinen V,Hartikainen P,Lyytinen J,Kaakkola S,Hänninen J,Löyttyniemi E,Kailajärvi M,Ruokoniemi P,Ellmén J

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Spontaneous reporting of adverse drug reactions (ADRs) is one approach to increasing our knowledge on the risks of drugs in clinical practice. Under-reporting is a shortcoming of this system. OBJECTIVES:To evaluate if repeated e-mails with attachments on ADR information can affect (1) the reporting of ADRs ...

journal_title：European journal of clinical pharmacology

authors： Johansson ML,Brunlöf G,Edward C,Wallerstedt SM

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:We assessed reported associations of CYP3A5 *1 allele with a delay in achieving target tacrolimus concentrations, and occurrence of biopsy-confirmed subclinical acute rejection (SAR) and chronic allograft nephropathy (CAN) in Japanese subjects. METHODS:Forty-one renal allograft recipients were studied. The tar...

journal_title：European journal of clinical pharmacology

authors： Satoh S,Saito M,Inoue T,Kagaya H,Miura M,Inoue K,Komatsuda A,Tsuchiya N,Suzuki T,Habuchi T

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:In Norway, very little data are available on the relation between the total number of research projects on the clinical development of drugs that have been started, the number of these projects in which the research phase has been completed and the number of projects for which results have been published. The...

journal_title：European journal of clinical pharmacology

authors： Hole OP,Nitter-Hauge S,Cederkvist HR,Winther FO

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:Body position may influence physiological characteristics, such as perfusion, gastrointestinal function and plasma volume. These characteristics may interact with key factors determining the pharmacokinetics of drugs (dissolution, absorption, distribution, metabolism, excretion). OBJECTIVES:Based on a sys...

journal_title：European journal of clinical pharmacology

authors： Queckenberg C,Fuhr U

更新日期：2009-02-01 00:00:00

abstract：:The opioid class of drugs, a large group, is mainly used for the treatment of acute and chronic persistent pain. All are eliminated from the body via metabolism involving principally CYP3A4 and the highly polymorphic CYP2D6, which markedly affects the drug's function, and by conjugation reactions mainly by UGT2B7. In ...

journal_title：European journal of clinical pharmacology

authors： Coller JK,Christrup LL,Somogyi AA

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The aim was to develop a model to describe the population pharmacokinetics of nevirapine in South African human immunodeficiency virus (HIV)-infected patients who were taking nevirapine-based antiretroviral therapy concomitantly or in the absence of rifampicin-based tuberculosis therapy. METHODS:Patients wer...

journal_title：European journal of clinical pharmacology

authors： Elsherbiny D,Cohen K,Jansson B,Smith P,McIlleron H,Simonsson US

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIs). METHODS:One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interviewing the patient and looking into his/her medical reco...

journal_title：European journal of clinical pharmacology

authors： Mannheimer B,Ulfvarson J,Eklöf S,Bergqvist M,von Bahr C

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:A population pharmacokinetic analysis was performed to define domperidone pharmacokinetic parameters in preterm neonates, as no pharmacokinetic data are available in this population. METHODS:An oral domperidone solution was administered (0.75 mg/kg per day) in 32 preterm neonates (64 samples). Domperidone plas...

journal_title：European journal of clinical pharmacology

authors： Dailly E,Drouineau MH,Gournay V,Rozé JC,Jolliet P

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To investigate possible differences in the time course of vasodilating effects of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in humans. METHODS:We measured forearm blood flow (FBF) by strain gauge plethymography and cyclic GMP spillover during and after intra-arterial infusions of BNP...

journal_title：European journal of clinical pharmacology

authors： Minami H,Yasu T,Tagawa T,Yamakawa K,Ueda S

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Spinal-cord injury (SCI) is a leading cause of neuropathic pain (NP). Current pharmaceutical treatments for NP in SCI patients are not effective. Two promising options are gabapentin (GP) and pregabalin (PB). Their predominant mechanism of action is believed to be the inhibition of calcium currents, leading ...

journal_title：European journal of clinical pharmacology

authors： Tzellos TG,Papazisis G,Amaniti E,Kouvelas D

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:Our aim was to observe the impact of CYP3A4*1G genetic polymorphism on lipid-lowering efficacy of statins. METHODS:We studied 217 unrelated hyperlipidemic patients who prospectively received atorvastatin and 199 patients who received simvastatin as a single-agent therapy (20 mg day(-1) p.o.) for 4 weeks. Genot...

journal_title：European journal of clinical pharmacology

authors： Gao Y,Zhang LR,Fu Q

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Pharmacovigilance, defined by the World Health Organisation as 'the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problem' plays a key role in ensuring that patients receive safe drugs. Our knowledge of a drug's adverse...

journal_title：European journal of clinical pharmacology

authors： Härmark L,van Grootheest AC

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To analyse the contribution of adverse drug reactions (ADR) to hospital readmissions. METHODS:This was a case-control study in which unscheduled admissions of patients who had been admitted to the hospital during the two previous months were assessed during a 21-month period. The patient was considered a cas...

journal_title：European journal of clinical pharmacology

authors： Ruiz B,García M,Aguirre U,Aguirre C

更新日期：2008-07-01 00:00:00

abstract：CASE REPORTS:Two women treated with agalsidase alpha for Fabry disease developed severe heart dysfunctions a few months after the beginning of enzyme replacement therapy (ERT). An adverse effect caused by the treatment was suspected; therefore we informed the French pharmacovigilance authorities about these two events....

journal_title：European journal of clinical pharmacology

authors： Mougenot P,Lidove O,Caillaud C,Arnaud P,Papo T

更新日期：2008-06-01 00:00:00

abstract：AIM:It has been reported that verapamil and atorvastatin are inhibitors of both P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A4, and verapamil is a substrate of both P-gp and CYP3A4. Thus, it could be expected that atorvastatin would alter the absorption and metabolism of verapamil. METHODS:The pharmaco...

journal_title：European journal of clinical pharmacology

authors： Choi DH,Shin WG,Choi JS

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of the two most common CYP2C9 variant alleles (*2 and *3) on the maintenance dose of warfarin and on the quality of anticoagulation control in Brazilians. METHODS:Patients (n = 103) initiated warfarin therapy with 5 mg/day (or 2.5 mg/day when over 80 years old). The international norma...

journal_title：European journal of clinical pharmacology

authors： Lima MV,Ribeiro GS,Mesquita ET,Victer PR,Vianna-Jorge R

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to investigate the effects of carbamazepine (CBZ) and oxcarbazepine (OXCBZ) on aminothiol levels, including homocysteine (Hcy), cysteine, and cysteinylglycine, in chronically treated patients. METHODS:Epileptic patients receiving CBZ or OXCBZ were recruited as part of routine clinica...

journal_title：European journal of clinical pharmacology

authors： Badiou S,Breton H,Peyriere H,Charasson V,Crespel A,Gelisse P,Cristol JP,Hillaire-Buys D

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:This work aimed at building a population pharmacokinetic (PK) model for lamivudine (LMV), stavudine (STV) and zidovudine (ZDV), estimating their inter and intraindividual PK variability and investigating the influence of different covariates. METHODS:Population PK of LMV, STV and ZDV was separately evaluated...

journal_title：European journal of clinical pharmacology

authors： Panhard X,Legrand M,Taburet AM,Diquet B,Goujard C,Mentré F,Cophar 1 - ANRS 102 Study Group.

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Monoamine oxidase inhibitors (MAOIs) are uncommonly used due to their high frequency of adverse effects, including tachycardia and hypertension. Recently, there has been renewed interest in the role of this class of drugs in treating a variety of psychiatric disorders. The clinical features of MAOI overdose ...

journal_title：European journal of clinical pharmacology

authors： Waring WS,Wallace WA

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:Designing a safe medication process requires the ability to model its reliability using methods such as probabilistic risk assessment (PRA). However, lack of data, especially on human-error probabilities (HEPs), limits its use. To assess whether small-scale simulations could help generate HEP data, a pilot s...

journal_title：European journal of clinical pharmacology

authors： Garnerin P,Pellet-Meier B,Chopard P,Perneger T,Bonnabry P

更新日期：2007-08-01 00:00:00

abstract：BACKGROUNDS AND AIMS:Development of safe and effective rescue regimens for eradication failure of Helicobacter pylori infection by standard regimens is an urgent task. We designed the prospective study to compare the efficacy of two rescue regimens after eradication failure by the standard triple therapy. METHODS:One ...

journal_title：European journal of clinical pharmacology

authors： Shirai N,Sugimoto M,Kodaira C,Nishino M,Ikuma M,Kajimura M,Ohashi K,Ishizaki T,Hishida A,Furuta T

更新日期：2007-08-01 00:00:00

abstract：:The effect of nevirapine once-daily dosing on the pharmacokinetics of methadone and its main metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, was evaluated in ten HIV positive patients on stable methadone therapy. Nevirapine 200 mg once daily was administered orally from day 1 to day 14. On day 15, nevir...

journal_title：European journal of clinical pharmacology

authors： Arroyo E,Valenzuela B,Portilla J,Climent-Grana E,Pérez-Ruixo JJ,Merino E

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:To investigate the drug interaction potential between itraconazole and nevirapine. METHODS:Our study was conducted in 12 healthy volunteers in two phases. In phase 1 (from days 1-28), all subjects were randomly assigned to a two-way crossover study of a nevirapine regimen (nevirapine 200 mg once daily for 7 ...

journal_title：European journal of clinical pharmacology

authors： Jaruratanasirikul S,Sriwiriyajan S

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVES:Digoxin is a well-known probe for the activity of P-glycoprotein. The objective of this work was to apply different methods for covariate selection in non-linear mixed-effect models to study the relationship between the pharmacokinetic parameters of digoxin and the genotype for two major exons located on the...

journal_title：European journal of clinical pharmacology

authors： Comets E,Verstuyft C,Lavielle M,Jaillon P,Becquemont L,Mentré F

更新日期：2007-05-01 00:00:00